Which of the following T-scores justifies pharmacologic treatment for postmenopausal women?

The T-score that justifies pharmacologic treatment for postmenopausal women is -2.5. This value falls below the threshold that indicates osteoporosis, a condition defined by a T-score of -2.5 or lower on a bone density test. At this level, the risk of fractures and other complications significantly increases, warranting intervention through medications such as bisphosphonates, hormone replacement therapy, or other treatments aimed at improving bone density and reducing fracture risk.

In clinical practice, T-scores between -1.0 and -2.5 are typically considered indicative of osteopenia, a precursor to osteoporosis, but they do not automatically necessitate pharmacological treatment. Instead, lifestyle modifications and monitoring may be recommended. A T-score higher than -1.0 indicates normal bone density, and while it suggests that a woman is at a lower risk of fractures, it does not typically justify the need for pharmacological intervention.