What role does ezetimibe play in dyslipidemia management?

Ezetimibe plays a vital role in the management of dyslipidemia by inhibiting cholesterol absorption in the intestine. This action specifically targets the dietary and biliary cholesterol that is absorbed through the gastrointestinal tract. By reducing the amount of cholesterol that enters the bloodstream, ezetimibe effectively lowers LDL cholesterol levels. This is particularly beneficial for patients who have elevated cholesterol levels that do not adequately respond to dietary changes alone.

In addition to its direct impact on cholesterol absorption, ezetimibe can be used in conjunction with statins, enhancing their cholesterol-lowering effects. This combination therapy can be particularly advantageous for patients who need significant lipid-lowering therapy to reach their target lipid levels for cardiovascular risk reduction. The ability of ezetimibe to lower LDL cholesterol without affecting its synthesis elsewhere in the body distinguishes it from other therapies that might increase the synthesis of cholesterol or alter triglyceride levels.