What is the recommended treatment for nongonococcal urethritis?

The recommended treatment for nongonococcal urethritis (NGU) focuses on eradicating the most common pathogens involved, particularly Chlamydia trachomatis. Azithromycin or doxycycline is effective due to their targeted action against Chlamydia, which is a significant cause of NGU.

Administering 1 gram of azithromycin as a single dose or 100 mg of doxycycline taken twice daily for a duration of 10 days effectively treats infections resulting from Chlamydia, providing a straightforward regimen that patients can easily follow. The single-dose aspect of azithromycin is particularly advantageous because it ensures higher adherence to treatment compared to a longer course, which can sometimes be difficult for patients.

While ciprofloxacin and levofloxacin are fluoroquinolone antibiotics that are effective against certain types of bacteria, they are not the first-line treatments for NGU specifically targeting Chlamydia. Metronidazole is used for bacterial vaginosis and certain anaerobic infections, but it doesn't standardly treat NGU.

The chosen answer reflects current guidelines and best practices in managing NGU effectively and safely.