What is a contraindication for Raloxifene?

Raloxifene is a selective estrogen receptor modulator (SERM) often used in the prevention and treatment of osteoporosis, particularly in postmenopausal women. One important contraindication for Raloxifene is its concurrent use with estrogen. This is because the combination can potentially increase the risk of adverse effects, such as thromboembolic events. Estrogen and Raloxifene have overlapping effects on estrogen receptors, and the safety profile may be compromised when they are used together.

In clinical practice, it is crucial to evaluate the medication regimen of patients, especially those who may be at higher risk for complications related to cardiovascular and thrombogenic events when combining therapies that affect the same hormonal pathways. Patients prescribed Raloxifene should be monitored for their overall health status and other medications they are taking to mitigate risks associated with concurrent estrogen use.