What common side effect is associated with Ospemifene?

Ospemifene is a selective estrogen receptor modulator (SERM) that is primarily used to treat dyspareunia (painful intercourse) associated with vaginal atrophy in postmenopausal women. One of the most notable side effects associated with Ospemifene is the occurrence of hot flashes. This side effect is attributable to its estrogenic activity, which can mimic some of the effects of estrogen and thus may lead to symptoms similar to those experienced during menopause, including hot flashes.

Understanding the hormonal mechanisms at play helps clarify why hot flashes can arise as a side effect. Ospemifene acts selectively on certain tissues, but it does not fully replace estrogen action, which can lead to fluctuations in temperature regulation, resulting in hot flashes. This is a common and significant effect that providers and patients need to be aware of when considering Ospemifene as a treatment option.